Hello, folks. I am in my first trimester of pregnancy. I must admit that I feel a lot of morning sickness. In order to relieve this sickness, I am thinking of taking Compazine. Doctors give unbiased, trusted information on whether Compazine can cause or treat Pregnancy: Dr. Kristle on compazine during pregnancy: This is a risk-benefit decision must be made between yourself and your physician. The risk varies by antidepressant, but the majority of the data indicate many antidepressants are likely safe in pregnancy. There is no controlled study in humans and anecdotal evidences show it does have teratogenic effects especially in the first trimester. Talk to your ob-gyn and don't take it until you do so. Talk to your ob-gyn and don't take it until you do so. Find patient medical information for Compazine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. I took Compazine every day for 30 days in my first trimester due to a severe form of morning sickness called hyperemesis. Although the side effects manifested themselves twice before I experienced full blown Tardive akathisia, my doctors forgot I was taking Compazine and failed to tell to me stop. WebMD provides important information about Compazine Oral such as if you can you take Compazine Oral when you are pregnant or nursing or If Compazine Oral dangerous for children or adults over 60. Taking Compazine with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking a sleeping pill, opioid pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression , or seizures. Nausea and vomiting of pregnancy, commonly known as “morning sickness,” affects approximately 80 percent of pregnant women. Although several theories have been proposed, the exact cause. References for pregnancy information Product Information. Compazine (prochlorperazine). SmithKline Beecham, Philadelphia, PA. Cerner Multum, Inc. Australian. Avoid in first trimester (fetal malformations and adverse pregnancy outcomes) Risk of uterine atony and peripartum Hemorrhage (but may be considered in debilitating Headache ) Consider intravenous Morphine.